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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RB1 All Species: 23.03
Human Site: S499 Identified Species: 42.22
UniProt: P06400 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06400 NP_000312.2 928 106159 S499 E V V M A T Y S R S T S Q N L
Chimpanzee Pan troglodytes XP_509777 1075 122190 S646 E V V M A T Y S R S T S Q N L
Rhesus Macaque Macaca mulatta XP_001100383 928 106126 S499 E V V M A T Y S R S T S Q N L
Dog Lupus familis XP_534118 897 103170 S468 E V V M A T Y S R S T S Q N L
Cat Felis silvestris
Mouse Mus musculus P13405 921 105320 S493 E V V M A T Y S R S T L Q H L
Rat Rattus norvegicus P33568 920 105007 S492 E V V M A T Y S R S M L Q N L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514098 917 104520 G490 E I V M A T Y G R S G S Q N N
Chicken Gallus gallus Q90600 921 104417 G489 E I V M A T Y G R T A S Q S D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001071248 903 102339 I481 A C A L E V V I A T Y V G S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395096 1006 113492 K508 E I V I Y S Y K S N D K I F P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790323 774 86478 T352 L L T G A R D T P S N V L C S
Poplar Tree Populus trichocarpa B9GLX8 1035 114624 K567 E L V V A T Y K T V T M L F P
Maize Zea mays Q3LXA7 1010 111475 K551 E L V L A T H K T V T M M F P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86.2 99.3 90 N.A. 90.4 89.7 N.A. 81.3 73 N.A. 53.9 N.A. N.A. 23 N.A. 26.4
Protein Similarity: 100 86.3 99.5 93 N.A. 94.9 95.1 N.A. 88.2 84.1 N.A. 70.9 N.A. N.A. 42.9 N.A. 42.6
P-Site Identity: 100 100 100 100 N.A. 86.6 86.6 N.A. 73.3 60 N.A. 0 N.A. N.A. 20 N.A. 13.3
P-Site Similarity: 100 100 100 100 N.A. 93.3 86.6 N.A. 80 80 N.A. 20 N.A. N.A. 46.6 N.A. 26.6
Percent
Protein Identity: 22.1 23.2 N.A. N.A. N.A. N.A.
Protein Similarity: 40.4 42.1 N.A. N.A. N.A. N.A.
P-Site Identity: 40 33.3 N.A. N.A. N.A. N.A.
P-Site Similarity: 53.3 53.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 0 85 0 0 0 8 0 8 0 0 0 0 % A
% Cys: 0 8 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 0 0 0 8 0 0 0 8 0 0 0 8 % D
% Glu: 85 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 24 0 % F
% Gly: 0 0 0 8 0 0 0 16 0 0 8 0 8 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 0 % H
% Ile: 0 24 0 8 0 0 0 8 0 0 0 0 8 0 0 % I
% Lys: 0 0 0 0 0 0 0 24 0 0 0 8 0 0 0 % K
% Leu: 8 24 0 16 0 0 0 0 0 0 0 16 16 0 47 % L
% Met: 0 0 0 62 0 0 0 0 0 0 8 16 8 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 8 8 0 0 47 8 % N
% Pro: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 24 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 62 0 0 % Q
% Arg: 0 0 0 0 0 8 0 0 62 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 8 0 47 8 62 0 47 0 16 16 % S
% Thr: 0 0 8 0 0 77 0 8 16 16 54 0 0 0 0 % T
% Val: 0 47 85 8 0 8 8 0 0 16 0 16 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 77 0 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _